The chicken major histocompatibility complex (MHC) represents a compact and evolutionarily distinct genomic region that plays a critical role in orchestrating adaptive immunity. Characterised by a ...

Antigen presentation by major histocompatibility complex (MHC) proteins is the caller ID of the immune system. On the cell surface, MHCs display peptides derived from cellular components or foreign ...

Within each individual’s immune system is a unique repertoire of billions of T cells patrolling the body to uncover and eliminate foreign threats. Yet this army is not foolproof and can miss the ...

Analyzing nearly 6,000 MHC-1 complexes, the research team discovered patterns that can identify these preferences and predict immune responses across a broad range of human populations. The HLA ...

Study introduces TRACeR-I, a protein platform with broad HLA compatibility, paving the way for advanced immune response engineering and disease-specific targeting. Study: Targeting peptide antigens ...

In the ever-evolving world of cell therapy, researchers often turn to T cells—a type of white blood cell—to transform the way we treat cancer. This is true for CAR T therapy, a modern cancer ...

By Tarun Sai Lomte New evidence shows that human M cells act as fully fledged antigen-presenting cells, processing and presenting gluten peptides through a dendritic cell-like pathway that may shape ...

To enhance CAR T therapies, scientists are actively studying TCR signaling and T-cell exhaustion mechanisms to improve CAR T persistence and function. Additionally, there is a growing trend towards ...

Neoantigen vaccines are at the forefront of cancer research, driving personalized immunotherapy and improving outcomes through targeted T-cell activation.