A rare inherited disorder, Xeroderma Pigmentosum (XP) is a photosensitive condition characterized by high susceptibility to skin cancers. XP follows the autosomal recessive pattern of inheritance.
Xeroderma pigmentosum, or XP, is a rare genetic disorder that prevents the skin from repairing sun damage. There are about 300 Americans currently living with XP, and the chances of being born in this ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, No. 14 (Jul. 3, 2001), pp. 7817-7822 (6 pages) Sun exposure has been clearly implicated in premature skin ...
New insight into how xeroderma pigmentosum causative gene products ensure the accuracy of DNA repair
XPC protein acts as a sensor to detect various abnormalities in the DNA structure. The faithful repair of DNA is ensured by using the basal transcription factor TFIIH and XPA protein to verify the ...
The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated. Relationships are self-held unless noted. I = Immediate Family ...
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What is xeroderma pigmentosum? The rare genetic disorder that forces people to avoid sunlight
Affected populations: Xeroderma pigmentosum is a rare genetic disorder that makes people's skin extremely sensitive to the harmful effects of ultraviolet (UV) light. Both males and females can develop ...
New insight into how xeroderma pigmentosum causative gene products ensure the accuracy of DNA repair
Our genomic DNA is continuously damaged by endogenous factors such as reactive oxygen species, and also by environmental factors such as ultraviolet light, radiation, and chemicals. Failure to repair ...
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