Like many developing tissues, the vertebrate neural tube is patterned by antiparallel morphogen gradients. To understand how these inputs are interpreted, we measured morphogen signaling and target ...

In a recent study published in Nature Communications, researchers examinea the effects of temporal morphogen gradient during neural induction (NI) on the formation of brain organoids. Study: Temporal ...

Scientists at St. Jude Children’s Research Hospital imaged cellular projections called cytonemes that transfer signals across long distances during development St. Jude Children’s Research Hospital ...

Human neural organoids, derived from pluripotent stem cells, enable the study of the highly regulated process of human brain development in vitro. In vivo, the process is shaped by strict time- and ...

Morphogens are signaling molecules that are vital for cell differentiation. These molecules directly influence cell differentiation, inducing specific cellular responses in relation to their ...

Researchers at Harvard Medical School and the Institute of Science and Technology (IST) Austria have discovered a key control mechanism that cells use to self-organize during early embryonic ...

Even when it’s not apparent, cells in our tissues and organs are constantly on the move. In fact, the ability of cells to get where they need to go is essential to our health and survival. Skin cells ...